Table 1 IC50 values of anticancer drugs against larval (NTS) and adult stages of S. mansoni
From: Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni
Compound | NTS: IC50 value [μM] | Adult S. mansoni: IC50 value [μM] | Adult S. mansoni: IC50 value in the presence of albumin [μM] |
|---|---|---|---|
Regorafenib | 6.9 | 1.0 | >> 33.3 |
Ponatinib | 0.2 | 1.1 | 20.2 |
Sorafenib | 4.1 | 1.1 | >> 33.3 |
Bosutinib | 0.8 | 1.5 | 14.8 |
Afatinib | 0.8 | 1.8 | 9.9 |
Sunitinib | 1.0 | 1.8 | 10.6 |
Crizotinib | 0.3 | 2.3 | 18.8 |
Trametinib | 4.6 | 4.1 | 21.0 |
Tamoxifen citrate | 2.0 | 5.7 | >> 33.3 |
Gefitinib | 7.8 | 8.3 | >> 33.3 |
Cabozantinib | 19.3 | 9.0 | >> 33.3 |
Celecoxib | 41.9 | 9.4 | >> 33.3 |
Vandetanib | 0.9 | 9.5 | >> 33.3 |
Idarubicin HCl | 12.7 | 16.2 | >> 33.3 |
Mechlorethamine HCl | > > 33.3 | 84.8 | Not done |