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Table 1 IC50 values of anticancer drugs against larval (NTS) and adult stages of S. mansoni

From: Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni

Compound NTS: IC50 value [μM] Adult S. mansoni: IC50 value [μM] Adult S. mansoni: IC50 value in the presence of albumin [μM]
Regorafenib 6.9 1.0 >> 33.3 
Ponatinib 0.2 1.1 20.2
Sorafenib 4.1 1.1 >> 33.3 
Bosutinib 0.8 1.5 14.8
Afatinib 0.8 1.8 9.9
Sunitinib 1.0 1.8 10.6
Crizotinib 0.3 2.3 18.8
Trametinib 4.6 4.1 21.0
Tamoxifen citrate 2.0 5.7 >> 33.3 
Gefitinib 7.8 8.3 >> 33.3 
Cabozantinib 19.3 9.0 >> 33.3 
Celecoxib 41.9 9.4 >> 33.3 
Vandetanib 0.9 9.5 >> 33.3 
Idarubicin HCl 12.7 16.2 >> 33.3 
Mechlorethamine HCl > > 33.3  84.8 Not done