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Table 2 Regional distribution of pfdhfr mutations

From: Polymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of India

  

pfdhfr genotypes

State

N

N51I

C59R

S108N

I164L

N

I

N + I

C

R

C + R

S

N

S + N

I

L

I + L

High transmission areas

         

 Jharkhand

84

84

-

-

8

46

30

3

55

26

76

4

4

 Odisha

70

67

2

1

22

40

8

21

43

6

66

1

3

 Total

154

151 (98.05 %)

2 (1.3 %)

1 (0.65 %)

30 (19.5 %)

86 (55.8 %)

38 (24.7 %)

24 (15.6 %)

98 (63.6 %)

32 (20.8 %)

142 (92.2 %)

5 (3.2 %)

7 (4.5 %)

Low transmission areas

         

 Andhra Pradesh

32

32

-

-

17

8

7

14

10

8

32

-

-

 Uttar Pradesh

31

31

-

-

4

23

4

-

31

-

31

-

-

 Total

63

63 (100 %)

-

-

21 (33.3 %)

31 (49.2 %)

11 (17.5 %)

14 22.2 %)

41 (65.08 %)

8 (12.7 %)

63 (100 %)

-

-

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