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Table 2 Model-estimated mf and L3 breakpoint values for achieving the successful interruption of LF transmission in each of the study sites investigated. Breakpoints are listed in terms of mf and L3 prevalences (%) at 95 % probability of elimination for two situations: 1) at the prevailing vector biting rates (ie., at the observed ABRs) and 2) at the threshold biting rate (TBR) at or below which LF transmission process cannot sustain itself regardless of the level of the infection in human hosts (see text). The first set of the threshold values (at study-specific ABR) is used in modeling the impact of mass drug administration (MDA) alone, while the 2nd set (ie., mf breakpoint values estimated at TBR) is applied for modeling the impact when MDA is supplemented by vector control (VC)

From: Bayesian calibration of simulation models for supporting management of the elimination of the macroparasitic disease, Lymphatic Filariasis

Study villages

Mean TBR

Mf bpts at ABR

L3 bpts at ABR

Mf bpts at TBR

L3 bpts at TBR

Peneng

5635

0.035429

0.001116

0.435501

0.021181

Albulum

11025

0.004885

0.000028

0.094346

0.010902

Yauatong

6185

0.002985

0.000021

0.066789

0.008942

Nanaha

9309

0.066568

0.001827

0.919664

0.022993

Ngahmbule

3365

0.058476

0.001996

0.45293

0.02599

Tawalani

10503

0.085207

0.001871

1.07946

0.02192

Jaribuni

13451

0.077864

0.002772

1.112716

0.022068

Tingrela

3310

0.042786

0.001659

0.559656

0.02453

Chiconi

7315

0.033768

0.000781

0.677308

0.018855

Masaika

5390

0.053393

0.002915

0.451975

0.451975

Kirare

1016

0.018212

0.000805

0.721577

0.061739

Alebtong

18703

0.007344

0.000088

0.22969

0.014427

Lwala

6201

0.015075

0.000217

0.259451

0.021331

Obalanga

1600

0.010066

0.000349

0.907932

0.047025

Kingwede

1363

0.022236

0.0021

0.089295

0.014983

Mao

20062

0.019268

0.002728

0.384838

0.038674

Mambrui

4445

0.075622

0.007421

0.885393

0.065253

Pondicherry

40223

0.000476

0.000025

0.041653

0.007822

Calcutta

86719

0.017295

0.001197

0.178704

0.019703

Vettavallam

66478

0.002706

0.000147

0.110904

0.017511

Pakistan

1311

0.034034

0.00316

0.659793

0.047162

Jakarta

88494

0.000171

0.000015

0.028576

0.00373

a P-value (An)

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

a P-value (Cx)

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

  1. a P-values are from results of Kruskal-Wallis rank sum tests for assessing differences in TBRs, L3 and mf breakpoints among sites within each of the Anopheline (An) and Culicine (Cx) LF settings