Table 1 The amino acid sequence of the derivatives of cecropin-TY1
From: A potent anti-inflammatory peptide from the salivary glands of horsefly
Mutant name | Amino acid sequence | Mutation sitea |
|---|---|---|
N39 mutant | GWLKKIGKKIERVGQNVRNAAISTLPIAQGAAGVAGALN-COOH | N39CONH2 → N39COOH |
W2 mutant | GALKKIGKKIERVGQNVRNAAISTLPIAQGAAGVAGALN-NH2 | W2 → A2 |
P26 mutant | GWLKKIGKKIERVGQNVRNAAISTL_IAQGAAGVAGALN-NH2 | lacked the hinge residue P26 |
KR mutant | GWLAAIGAAIEAVGQNVANAAISTLPIAQGAAGVAGALN-NH2 | K4 → A4, K5 → A5, K8 → A8, K9 → A9, R12 → A12, R18 → A18 |
scr-cec-TY1 | RGQANILAGKNIKIRSGAAAGVGKTPQKANVEVLALGIW-NH2 | Scrambled cecropin-TY1, disrupted the helices |