|
Basic model structure
| | |
|
Number and type of spatial locations modelled
|
Single place
|
Single place
|
|
Population-based or individual-based
|
Individual-based regarding humans and worms
|
Population-based
|
|
Way of representing infection in hosts
|
Presence and density at individual level
|
Mean density in population subgroups (e.g. age, sex, treatment compliance group). Prevalence as a function of mean density assuming an underlying negative binomial distribution
|
|
Role of chance
|
Stochastic
|
Deterministic
|
|
Interventions considered in previous publications
|
Mass treatment, selective treatment (test and treat), vector control,
|
Mass treatment, vector control
|
|
Features included in the model
| | |
|
Human population demographics
|
Birth and death rate dynamically modelled; age and sex composition
|
Birth and death rate, age and sex composition
|
|
Heterogeneities in the human population
|
Age, sex, life expectancy, level of exposure to blackflies, compliance with MDA, efficacy of treatment
|
Age, sex, life expectancy, level of exposure to blackflies, compliance with MDA
|
|
Blackfly population density
|
Fixed input as annual biting rate (ABR); seasonal monthly biting rates
|
Fixed input as ABR; seasonality in biting rates can be included
|
|
Exposure to blackfly vectors
|
Heterogeneous (dependent on age, sex, personal attractiveness to blackflies)
|
Heterogeneous (dependent on age and sex)
|
|
Uptake of infection by blackfly vectors
|
Varying non-linearly (density-dependent) with infection intensity in human hosts
|
Varying non-linearly (density-dependent) with infection intensity in human hosts
|
|
Infection in blackfly vectors
|
Density (average L3 load per fly)
|
Density (average L3 load per fly)
|
|
Excess mortality of infected flies
|
No
|
Yes
|
|
Parasite acquisition in humans
|
Proportional to mean number of L3 larvae inoculated, denoted by the success ratio
|
Non-linearly (density-dependent) related to rate of exposure to L3 larvae
|
|
Infection in humans
|
Density (immature or mature worms, mf per skin snip)
|
Density (non-fertile and fertile worms, mf per mg of skin)
|
|
Diagnostic outcomes
|
Mf count sampling to relate model predictions to data
|
Sampling process and diagnostic performance of skin snipping not yet included
|
