Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen

Parasites & Vectors

Table 2 Gene positions and lengths in the T. lewisi maxicircle

Gene	RNA editing	T. lewisi position	T. lewisi length	T. cruzi length^d	T. brucei length^e	L. tarentolae length^e
12S rRNA	/	1–1168	1168	1161	1149	1173
9S rRNA	/	1218–1825	608	608	611	611
ND8	Extensive	1865–2149	285	279	266	266
DN9 ^a	Extensive	2218–2567	350	338	321	291
MURF5 ^a	None	2581–2821	241	264	234	303
ND7 ^b	Extensive	2887–3657	771	755	702	1144
COIII ^b	Extensive	3741–4154	414	424	439	852
Cyb	Minor	4242–5321	1080	1080	1080	1079
ATPase6 ^b	Extensive	5359–5662	304	336	369	603
MURF1/(ND2)^a	None	5704–7044	1341	1341	1237	1332
GR3 ^c	Extensive	7033–7155	~123	~119	~164	167
ND1 ^a	None	7172–8113	942	942	957	942
COII	Minor	8115–8743	629	629	626	629
MURF2	Minor	8770–9822	1053	1056	1041	1045
COI ^a	None	9813–11462	1650	1650	1734	1650
GR4 ^a	Extensive	11508–11719	212	207	185	189
ND4	None	11824–13137	1314	1314	1311	1314
ND3 ^a	Extensive	13126–13312	187	193	256	187
RPS12	Extensive	13383–13572	190	191	172	182
ND5	None	13597–15369	1773	1770	1770	1773

Gene positions are shown relative to the start of the gene 12S rRNA
^apresents those genes that are encoded by the reverse strand
^bpresents those genes that are 5’-edited in L. tarentolae
^cpresents the two end positions of GR3 from T. lewisi, T. cruzi and T. brucei are uncertain
^dpresents the maxicircle gene lengths of T. cruzi that are cited from the paper of Ruvalcaba-Trejo [16]
^epresents calculations of the maxicircle gene lengths of T. brucei and L. tarentolae that are based on the data from GenBank (M94286.1 and M10126.1, respectively)

ISSN: 1756-3305