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Table 3 Summary of approaches used to estimate egg reduction rates among children infected with schistosomes following treatment with praziquatel

From: New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel

Approach Method Required parametric assumptions Inference
Model-free Sample statistics • None • Population average estimates
Model-based Marginal models • Variance to mean relationship • Correlation structure among repeated measures • Population average estimates • Covariate effects
  Conditional mixed models • Conditional distribution of data • Distribution of random effects • Individual estimates • Covariate effects
  Bayesian conditional mixed models • Conditional distribution of data • Distribution of random effects • Prior distribution of parameters • Individual estimates • Covariate effects • Fully integrated parameter uncertainty