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Table 3 Summary of approaches used to estimate egg reduction rates among children infected with schistosomes following treatment with praziquatel

From: New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel

Approach Method Required parametric assumptions Inference
Model-free Sample statistics • None • Population average estimates
Model-based Marginal models • Variance to mean relationship
• Correlation structure among repeated measures
• Population average estimates
• Covariate effects
  Conditional mixed models • Conditional distribution of data
• Distribution of random effects
• Individual estimates
• Covariate effects
  Bayesian conditional mixed models • Conditional distribution of data
• Distribution of random effects
• Prior distribution of parameters
• Individual estimates
• Covariate effects
• Fully integrated parameter uncertainty