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Table 2 Study 2: Knock-down effect at 5 min and arithmetic mean flea counts and preventive efficacies at 2 h and 6 h (speed of kill) of the combination of permethrin and fipronil (group 2) and a combination of dinetofuran + permethrin + pyriproxyfen (Group 3) compared to control (Group 1)

From: Knock-down and speed of kill of a combination of fipronil and permethrin for the prevention of Ctenocephalides felis flea infestation in dogs

  Knock-down effect (%) at 5 min Mean flea counts and preventive efficacy
at 2 h at 6 h
Group 2 Group 3 Group 1 Group 2 Group 3 Group 1 Group 2 Group 3
Fipronil + permethrin Dinetofuran + permethrin + pyriproxyfen Control Fipronil + permethrin Dinetofuran + permethrin + pyriproxyfen Control Fipronil + permethrin Dinetofuran + permethrin + pyriproxyfen
D2 32.5 %a 17.1 % 94,8 9.6 (89.8 %) 26.3 (72.3 %) 89.8 0.6 (99.3 %) 0.8 (99.2 %)
D7 31.9 %a 6.6 % 88.6 0.9 (99.0 %) 8.1 (90.8 %) 87.8 0.0 (100.0 %) 0.9 (99.0 %)
D14 16.4 %a 3.8 % 84.5 3.3 (96.2 %) 9.5 (88.8 %) 81.8 0.3 (99.7 %) 1.8 (97.9 %)
D21 33.7 %a 10.1 % 97.3 5.4a (94.5 %) 17.8 (81.7 %) 91.4 0.5 (99.5 %) 2.1 (97.7 %)
D28 29.9 %a 6.5 % 94.3 14.0 (85.1 %) 17.4 (81.6 %) 82.1 1.3 (98.5 %) 1.9 (97.7 %)
  1. a statistically significant increased efficacy in the fipronil/permethrin group compared to the dinetofuran + permethrin + pyriproxyfen group (p < 0.05)