Table 1 Mean live flea counts and efficacy relative to placebo at 8 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or spinosad/milbemycin oxime on Day 0

Placebo

Range

80–100

45–100

71–100

70–100

85–100

74–100

A. mean

91.8

86.0

87.4

87.8

96.1

86.6

G. mean¹

91.5^a

83.9^a

86.7^a

87.3^a

96.0^a

86.3^a

Sarolaner

Range

0–0

0–1

0–0

0–2

0–18

0–56

A. mean

0.0

0.1

0.0

0.3

3.0

14.9

Efficacy (%)

100

99.9

100

99.7

96.9

82.8

G. mean¹

0.0^b

0.1^b

0.0^b

0.1^c

0.8^c

5.2^c

Efficacy (%)

100

99.9

100

99.8

99.1

94.0

P-value vs.placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Spinosad/milbemycin oxime

Range

0–0

0–0

0–0

0–50

0–69

0–73

A. mean

0.0

0.0

0.0

9.1

22.3

38.4

Efficacy (%)

100

100

100

89.6

76.9

55.7

G. mean¹

0.0^b

0.0^b

0.0^b

2.6^b

5.3^b

23.1^b

Efficacy (%)

100

100

100

97.0

94.4

73.2

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

0.0021

P-value vs. sarolaner

1.000

0.8420

1.000

0.0085

0.0049

0.0020