Table 2 Mean live Amblyomma americanum counts and efficacy relative to placebo at 12 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0¹

Placebo

Range

4–20

13–33

7–27

11–34

15–36

5–26

A. mean

12.4

21.5

20.1

20.9

26.9

18.4

G. mean²

11.2^a

20.5^a

18.9^a

19.5^a

25.7^a

16.6^a

Sarolaner

Range

0–16

9–22

9–18

10–23

8–34

12–28

A. mean

3.8

15.0

12.6

16.9

16.9

18.4

Efficacy (%)

69.7

30.2

37.3

19.2

37.2

0.0

G. mean²

1.9^b

14.4^a

12.4^a

16.2^a

15.5^b

17.6^a

Efficacy (%)

82.8

29.6

34.4

17.0

39.6

0.0

P-value vs. placebo

<0.0001

0.1392

0.0791

0.4291

0.0338

0.8025

Afoxolaner

Range

0–15

8–27

8–21

9–25

8–41

12–21

A. mean

6.2

17.7

13.7

16.7

21.8

17.5

Efficacy (%)

50.2

17.8

32.1

20.2

18.8

4.8

G. mean²

4.1^b

16.4^a

12.6^a

15.4^a

18.9^a,b

16.8^a

Efficacy (%)

63.9

20.1

33.2

21.3

26.6

0.0

P-value vs. placebo

0.0008

0.4068

0.1427

0.3790

0.2500

0.9633

P-value vs. sarolaner

0.0657

0.6850

0.9533

0.8665

0.5317

0.8806