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Table 2 Mean live Amblyomma americanum counts and efficacy relative to placebo at 12 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 01

From: Comparative speed of kill of sarolaner (Simparica) and afoxolaner (NexGard®) against induced infestations of Amblyomma americanum on dogs

Treatment   Day of treatment or re-infestation
  0 7 14 21 28 35
Placebo Range 4–20 13–33 7–27 11–34 15–36 5–26
A. mean 12.4 21.5 20.1 20.9 26.9 18.4
G. mean2 11.2a 20.5a 18.9a 19.5a 25.7a 16.6a
Sarolaner Range 0–16 9–22 9–18 10–23 8–34 12–28
A. mean 3.8 15.0 12.6 16.9 16.9 18.4
Efficacy (%) 69.7 30.2 37.3 19.2 37.2 0.0
G. mean2 1.9b 14.4a 12.4a 16.2a 15.5b 17.6a
Efficacy (%) 82.8 29.6 34.4 17.0 39.6 0.0
P-value vs. placebo <0.0001 0.1392 0.0791 0.4291 0.0338 0.8025
Afoxolaner Range 0–15 8–27 8–21 9–25 8–41 12–21
A. mean 6.2 17.7 13.7 16.7 21.8 17.5
Efficacy (%) 50.2 17.8 32.1 20.2 18.8 4.8
G. mean2 4.1b 16.4a 12.6a 15.4a 18.9a,b 16.8a
Efficacy (%) 63.9 20.1 33.2 21.3 26.6 0.0
P-value vs. placebo 0.0008 0.4068 0.1427 0.3790 0.2500 0.9633
P-value vs. sarolaner 0.0657 0.6850 0.9533 0.8665 0.5317 0.8806
  1. 1 n = 6 for afoxolaner, n = 8 for placebo and sarolaner groups
  2. 2Geometric means within columns with the same superscript are not significantly different (P > 0.05)