Fig. 1

Summary of functional enrichment analyses of microRNAs (miRNAs) in adult worms of Toxocara canis. In both male and female worms, miRNAs (i.e. those for which homologs have been described previously for other nematodes) were predicted to be involved in regulating embryonic morphogenesis, hemidesmosome assembly, genetic information processing (including spliceosome and proteasome) and biotin metabolism (right box). Differentially transcribed miRNAs were predicted to be mainly associated with male sex determination, purine nucleotide metabolism process, germ cell repulsion, male genitalia morphogenesis and Fc gamma R-mediated phagocytosis exclusively in the male worm (top box), and with embryonic morphogenesis, store-operated calcium entry, Acyl-CoA metabolic process, nematode larval development and sphingolipid metabolism in the female worm (bottom box)