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Table 1 Mean (arithmetic) plasma pharmacokinetic parameters for fluralaner in dogs following single topical and i.v. administration

From: Comparative pharmacokinetics of fluralaner in dogs and cats following single topical or intravenous administration

Parameters Topical Topical Topical Intravenousb
12.5 mg/kg 25.0 mg/kg 50.0 mg/kg 12.5 mg/kg
n = 6 n = 6 n = 6 n = 6
Cmax (ng/mL) 358 ± 94 727 ± 191 1698 ± 318 7109 ± 908
tmax a (day) 42 (range 21–63) 25 (range 14–56) 25 (range 7–42) n/a
AUC(0→t) (day*ng/ml) 18933 ± 3599 41243 ± 7467 85852 ± 17283 87198 ± 11835
AUC(0→∞) (day*ng/ml) 19577 ± 3982 43375c  ± 8752 93468c ± 20424 87779 ± 12004
t1/2 (day) 17 ± 4 21c ± 3 17c  ± 3 15 ± 2
tlast (day) 112 ± 0 112 ± 0 112 ± 0 109 ± 9
MRT (day) 47 ± 1 48c ± 4 43c  ± 6 20 ± 3
Cl (L/kg/day) n/a n/a n/a 0.14 ± 0.02
Vz (L/kg) n/a n/a n/a 3.1 ± 0.5
F (%) 22 ± 4 24 ± 4 25 ± 5 n/a
  1. aMedian, other values are mean ± standard deviation
  2. bData previously published in Kilp et al. [4]; cMean consits of n = 4 (50.0 mg/kg)/ n = 5 (25.0 mg/kg) values; other values excluded as considered unreliable; see Methods
  3. n/a - not applicable