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Table 2 Mean (arithmetic) plasma pharmacokinetic parameters for fluralaner in cats following single topical and i.v. administration

From: Comparative pharmacokinetics of fluralaner in dogs and cats following single topical or intravenous administration

Parameters Topical Topical Topical Intravenous
20.0 mg/kg 40.0 mg/kg 80.0 mg/kg 5.0 mg/kg
n = 6 n = 6 n = 6 n = 6
Cmax (ng/ml) 757 ± 328 1850 ± 808 2399 ± 865 4302 ± 435
tmax a (day) 9 (range 5–10) 6 (range 3–14) 9 (range 7–21) n/a
AUC(0→t) (day*ng/ml) 22065 ± 7996 48161 ± 15294 89193 ± 21413 21863 ± 2160
AUC(0→∞) (day*ng/ml) 22276 ± 7996 48400 ± 15177 89690 ± 21479 22141 ± 2105
t1/2 (day) 13 ± 2 12 ± 4 12 ± 1 11 ± 1
tlast (day) 93 ± 14 102 ± 12 110 ± 6 68 ± 7
MRT (day) 24 ± 3 23 ± 7 29 ± 5 15 ± 1
Cl (L/kg/day) n/a n/a n/a 0.23 ± 0.02
Vz (L/kg) n/a n/a n/a 3.5 ± 0.5
F (%) 25 ± 9 28 ± 9 25 ± 6 n/a
  1. aMedian, other values are mean ± standard deviation
  2. n/a - not applicable