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Table 3 Summary of parameters based on IFN-γ producer versus IFN-γ non-producer dogs

From: Leishmania infantum-specific production of IFN-γ and IL-10 in stimulated blood from dogs with clinical leishmaniosis

Clinical staging

IFN-γ producers (mean ± standard deviation)

IFN-γ non-producers (mean ± standard deviation)

Number of dogs

IFN-γ LSA (pg/ml)

IL-10 LSA (pg/ml)

PCR (parasite/ml)

ELISA (EU)

Number of dogs

IFN-γ LSA (pg/ml)

IL-10 LSA (pg/ml)

PCR (parasite/ml)

ELISA (EU)

I

9

2247 ± 2749

18 ± 20

4.1 ± 11

50 ± 53

1

0 ± 0

15 ± 0

0 ± 0

13 ± 0

IIa

17

3031 ± 5240

12 ± 16

2 ± 4

2660 ± 7140

10

0 ± 0

3 ± 8

12 ± 14

10,418 ± 15,420

IIb

3

1616 ± 1860

14 ± 23

0.1 ± 0.1

14,373 ± 15,473

6

0 ± 0

3.3 ± 8

162 ± 360

27,744 ± 32,476

III

5

846 ± 665

29 ± 18

12 ± 19

7755 ± 5590

5

0 ± 0

0 ± 0

29 ± 31

17,077 ± 28,897

IV

1

375 ± 0

19 ± 0

35 ± 0

73,701 ± 0

3

0 ± 0

0 ± 0

8438 ± 14,419

44,967 ± 51,408

Total

35

2320 ± 3961a

16 ± 18b

5 ± 10

5750 ± 14,082

25

0 ± 0

2.4 ± 7

1100 ± 5112c

19,638 ± 28,596d

  1. Statistical study was performed to compare IFN-γ producers versus non-IFN-γ producers. Letters a to d correspond to statistically significant differences
  2. Results for IFN-γ LSA, IFN-γa producers > non-IFN-γ producers (Mann-Whitney U-test: Z = -6.7, P < 0.0001)
  3. Results for IL-10 LSA, IFN-γb producers > non-IFN-γ producers (Mann-Whitney U-test: Z = -3.60, P < 0.0001)
  4. Results for PCR, IFN-γc producers< non-IFN-γ producers (Mann-Whitney U-test: Z = -3.2, P = 0.001)
  5. Results for ELISA units, IFN-γd producers< non-IFN-γ producers (Mann-Whitney U-test: Z = -3.2, P = 0.001)
  6. Abbreviations: LSA L. infantum soluble antigen