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Table 3 Development of East Coast fever symptoms in cattle vaccinated with the multivalent antigen cocktail after exposure to Theileria parva-infected ‘low-line’ ticks

From: Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission

   Vaccinated cattle (n = 18) Control cattle (n = 10) P-value
Pyrexiaa,b Number of animals where symptom observed (%) 15 (83 %) 9 (90 %) < 0.999d
Day of first onset 10.3 (1.2) 11.1 (1.8) 0.801e
Duration 5.8 (0.9) 5. 6 (1.4) 0.803e
Regional lymph node parasitosisa Number of animals where symptom observed (%) 13 (72 %) 9 (90 %) 0.375d
Day of first onset 13.5 (0.6) 14.0 (1.1) 0.774e
Duration 4.2 (0.7) 3.7 (0.9) 0.547e
Contra-lateral lymph node parasitosisa Number of animals developing symptom (%) 8 (44 %) 6 (60 %) 0.695d
Day of first onset 16.1 (0.5) 17.2 (0.6) 0.211e
Duration 3 (0.8) 2.5 (1.7) 0.825e
Piroplasma Number of animals where symptom observed (%) 5 (28 %) 4 (40 %) 0.678d
Day of first onset 17.6 (0.6) 17.0 (0.4) 0.722e
Duration 3 (0.6) 3 (0.7) < 0.999e
Nested p104 PCR detection of parasites   17 (94 %) 9 (90 %) < 0.999d
PIM antibodies Number of animals where antibodies detected (%) 18 (100 %) 10 (100 %) < 0.999d
Average PP valuec 44.7 ± 16.1 53.4 ± 22.8 0.249e
  1. aValues are displayed as the average day of first detection (SEM). Where symptoms were not observed in an animal, no values are reflected
  2. bPyrexia was defined as rectal temperature exceeding 39.5 °C
  3. cThe average Percentage Positive (PP) value calculated as the (OD of test sample/OD of strong positive) × 100
  4. dFischer’s exact test
  5. eMann-Whitney test