Fig. 5From: Increased expression of ATP binding cassette transporter genes following exposure of Haemonchus contortus larvae to a high concentration of monepantel in vitroIVM sensitivity in Kirby and WAL L3 stage larvae following monepantel pre-exposure. Sensitivity to IVM was measured using migration assays following pre-exposure to MPL250μg/ml in Kirby (a after 3 h pre-exposure and b after 6 h pre-exposure) and WAL (c after 3 h pre-exposure and d after 6 h pre-exposure) L3 stage larvae, compared to L3 pre-exposed to DMSO only. DMSO pre-exposure shown with solid lines and closed symbols, MPL pre-exposure shown with dashed lines and open symbols. The data points marked with * show significant differences (P < 0.05) in percent migration between MPL- and DMSO- pre-exposure groups (t-test). Each data point represents mean ± standard error of the mean (SEM), n = 9 (pooled data from three experiments, each with assays in triplicate)Back to article page