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Table 1 Relative transcription levels of ABC transporter genes in the 250 μg/ml MPL-treated Kirby and WAL larvae compared to DMSO-treated controls. Significant (P < 0.05) increases or decreases in transcription in the MPL-treated larvae compared to the DMSO-treated larvae are indicated by * and #, respectively

From: Increased expression of ATP binding cassette transporter genes following exposure of Haemonchus contortus larvae to a high concentration of monepantel in vitro

Gene

Kirby

WAL

3 h

6 h

24 h

3 h

6 h

24 h

Pgp 1

0.39

1.4

1.0

2.5

0.77

0.98

Pgp 2

0.29#

2.6

2.2*

7.9*

2.1

2.2*

Pgp 3

0.94

1.8

1.1

2.7

0.68

1.2

Pgp 9.1

0.46

1.4

1.1

8.4*

1.2

1.0

Pgp 9.2

1.9

1.4

1.2

1.8

0.97

0.95

Pgp 9.3

1.2

1.0

0.84

1.0

1.4

0.72#

Pgp 10

0.41

0.35

0.62#

1.8

0.76

0.59#

Pgp 11

0.69

2.3

8.8*

11.7*

7.4*

6.9*

Pgp 12

5.4*

9.1*

2.3*

9.4*

8.2*

2.9*

Pgp 14

8.7*

4.6*

2.4*

12.2*

5.5*

2.6*

Pgp 16

1.3

1.1

0.52#

0.51

1.0

0.79#

MRP 1

1.01

1.9

1.8*

1.2

1.0

1.5*

MRP 5

1.2

0.9

0.73#

1.4

0.88

0.79#

ABCF 1

0.43

0.8

0.97

2.0

0.87

0.92

ABCF 2

1.1

0.97

1.1

2.1

1.0

1.0

HAF-6

0.58#

0.54

0.94

20.5*

0.85

1.0

  1. # denotes decreased gene transcription following MPL exposure compared to DMSO-treated controls
  2. * denotes increased gene transcription following MPL exposure compared to DMSO-treated controls
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