Table 1 Miltefosine susceptibility of L. donovani populations determined by EC₅₀ assays. Upon analysis, parasite lines show increasing degrees of resistance to HePC as selection pressure increases (denoted as LdR10 and LdR30, respectively). Transgenic lines over-expressing HSPA9B show increased sensitivity to drug treatment as compared to their controls. Sensitivity reverts back to WT like values upon generating mutations in the ATP binding domain (GxD, GxD, referred to as SM) or both the ATP and peptide binding domains (GxD, GxD, FxV, referred to as DM)

From: A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani