Functional characterization of Plasmodium berghei PSOP25 during ookinete development and as a malaria transmission-blocking vaccine candidate

Table 2 Oocyst number per midgut in mosquitoes 10 days after feeding on mice infected with the WT and the Δpsop25 parasites

	No. of mosquitoes (infected/dissected)	Prevalence of infection (%)^a	Mean oocyst (IQR)^b	SEM^c	Reduction in oocyst intensity (%)^d	P
Wild type	29/30	99.7	96.93 (43.00–139.8)	12.01
Δpsop25	27/30	90	29.67 (10.25–43.25)	4.481	67.26	< 0.001

^aThe prevalence of infection was calculated by the number of mosquitoes with oocysts/total mosquitoes dissected in each group × 100%
^bIQR, inter-quartile range
^cStandard error of the mean
^dThe percent reduction in oocyst intensity was calculated as (mean oocyst intensity _WT – mean oocyst intensity _Δpsop25)/mean oocyst intensity _WT × 100%

ISSN: 1756-3305