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Table 1 The top 25 genes enriched in S. japonicum cercariae, hepatic schistosomula, mixed adult worms and eggs
| NCBI Nucleotide | NCBI Protein | Annotation | FC |
|---|---|---|---|
| Enriched in cercariae | |||
| AY811679.1 | AAX27568.2 | Tegumental antigen | 94.004 |
| AY812964.1 | AAW24696.1 | Lysophosphatidic acid phosphatase type 6 | 89.015 |
| AY808793.1 | AAX24682.2 | Krueppel-like factor 11 | 20.463 |
| AY814888.1 | AAP06195.1 | Hypothetical protein | 20.323 |
| AY915869.1 | AAX31090.1 | UPF0506 domain containing protein | 15.144 |
| AY811006.1 | AAX26895.2 | Putative sodium-dependent transporter | 14.884 |
| FN319257.1 | CAX74986.1 | Ribosomal protein S6 kinase beta-2 | 13.668 |
| AY813254.1 | CAX83692.1 | Gag-Pol polyprotein | 11.090 |
| AY812158.1 | AAX28047.2 | Calcium-dependent secretion activator | 10.898 |
| FN327240.1 | CAX82964.1 | UPF0364 protein | 10.005 |
| FN319112.1 | CAX74840.1 | Anti-inflammatory protein 16 | 9.750 |
| AY809199.1 | AAX25088.2 | Dynein light intermediate chain 1 cytosolic | 9.060 |
| AY815066.1 | AAW26798.1 | Calpain | 8.200 |
| FN314407.1 | CAX70140.1 | Rab-protein 11 | 8.118 |
| AY813232.1 | AAW24964.1 | DM9 domain-containing protein | 7.327 |
| AY915497.1 | AAX30718.2 | Homeobox protein SMOX-1 | 7.320 |
| AY813605 | AAW25337.1 | Hypothetical protein | 7.234 |
| FN319705.1 | CAX75429.1 | THO complex subunit 1 | 6.827 |
| AY813585.1 | AAW25317.1 | Hypothetical protein | 6.756 |
| AY811834.1 | AAX27723.2 | AMP deaminase | 6.524 |
| AY813088.1 | AAW24820.1 | Hypothetical protein | 6.357 |
| FN314484 | CAX70217.1 | Hypothetical protein | 6.196 |
| AY811464.1 | ABA40369.1 | 5′-AMP-activated protein kinase subunit gamma-1 | 6.165 |
| EU046089.1 | AAW25910.1 | Cercarial stage-specific protein Sj20H8 | 6.075 |
| AY808884.1 | AF129816_1 | Retinoid X receptor RXR-2 | 6.011 |
| Enriched in hepatic schistosomula | |||
| AY809629.1 | AAX25518.2 | Hypothetical protein | 33.897 |
| AY810683 | AAX26572.2 | Putative collagen alpha-1(V) chain precursor | 9.200 |
| AY815366.1 | AAW27592.1 | Alpha-ketoglutarate-dependent dioxygenase alkB 6 | 6.931 |
| AY813429.1 | AAW25161.1 | Hypothetical protein | 5.290 |
| AY810949.1 | AAX26838.2 | Homeobox protein engrailed-like SMOX-2 | 5.057 |
| EZ000055.1 | ACE06835.1 | Vacuolar protein sorting-associated protein 29 | 5.021 |
| AY810397.1 | AAX26286.2 | Protocadherin Fat 4 | 4.839 |
| AY811075.1 | AAX26964.2 | Hypothetical protein | 4.831 |
| AY815532.1 | AAW27264.1 | Hypothetical protein | 4.727 |
| AY814356 | AAW26088.1 | RhoGAP domain containing protein | 4.610 |
| AY811025.1 | AAX26914.2 | Serine/threonine-protein kinase Sgk1 | 4.342 |
| AY809477.1 | AAX25366.2 | SAM and SH3 domain-containing protein 1 | 4.248 |
| FN314446.1 | CAX70179.1 | Annexin A3 (Annexin III) | 4.037 |
| AY814048.1 | AAW25780.1 | Basic proline-rich protein-like isoform | 3.967 |
| AY808501.1 | AAR28090.2 | Nuclear receptor subfamily 4 group A | 3.956 |
| AY809584.1 | AAX25473.2 | Hypothetical protein | 3.894 |
| AY812287.1 | AAX28176.2 | Run domain Beclin-1 interacting and cysteine-rich containing protein | 3.806 |
| AY813648.1 | AAW25380.1 | Hypothetical protein | 3.439 |
| AY915540.1 | ABA40872.1 | Leishmanolysin-like peptidase | 3.419 |
| AY812557.1 | AAX28446.2 | Aromatic-L-amino-acid decarboxylase | 3.335 |
| AY808377.1 | AAX24266.2 | Regulator of G-protein signaling 3 | 3.250 |
| FN313634.1 | CAX69368.1 | Collagen alpha-2(I) chain | 3.244 |
| AY813683.1 | AAW25415.1 | Delphilin | 3.240 |
| AY812144.1 | AAX28033.2 | Hypothetical protein | 3.212 |
| AY813563 | AAW25295.1 | Hypothetical protein | 3.203 |
| Enriched in mixed adult worms | |||
| FN314868.1 | CAX70600.1 | Asparagine-rich antigen Pfa35-2 | 1651.245 |
| EZ000096 | ACE06876.1 | Putative eggshell protein precursor | 934.084 |
| FN314999 | CAX70731.1 | TES domain containing protein | 704.455 |
| AY813556.1 | AAW25288.1 | Hypothetical protein | 692.180 |
| AY814029 | AAW25761.2 | Stress protein DDR48 (DNA damage-responsive protein 48) | 678.514 |
| FN313935.1 | CAX69669.1 | Stress protein DDR48 (DNA damage-responsive protein 48) | 665.581 |
| FN317103 | CAX72834.1 | Stress protein DDR48 (DNA damage-responsive protein 48) | 645.627 |
| FN313912 | CAX69646.1 | TES domain containing protein | 604.574 |
| FN313715.1 | CAX69449.1 | TES domain containing protein | 561.444 |
| AY812810.1 | AAW24542.1 | Histidine-rich glycoprotein precursor | 526.698 |
| FN315504.1 | CAX71236.1 | TES domain containing protein | 517.929 |
| AY815518 | AAW27250.1 | TES domain containing protein | 489.519 |
| FN314997 | CAX70729.1 | TES domain containing protein | 422.784 |
| AY813405 | AAW25137.1 | TES domain containing protein | 407.588 |
| AY815264.1 | AAW26996.1 | Tyrosinase 1 | 346.094 |
| AY812315.1 | AAX28204.2 | Hypothetical protein | 330.410 |
| FN330801 | CAX83018.1 | Stress protein DDR48 (DNA damage-responsive protein 48) | 235.455 |
| AY814142.1 | AAW25874.1 | Putative FAM75 family member | 224.325 |
| AY812904 | AAW24636.1 | Tyrosinase 2 | 209.523 |
| FN315510.1 | CAX71242.1 | Hypothetical protein | 164.941 |
| AY814814 | AAW26546.1 | Cadherin | 145.264 |
| AY815418 | AAW27150.1 | Female-specific protein 800 | 135.097 |
| FN316955 | CAX72686.1 | Prostatic spermine-binding protein precursor | 132.448 |
| AY222885 | AAP05897.1 | Stress protein DDR48 (DNA damage-responsive protein 48) | 127.238 |
| FN314903.1 | CAX70635.1 | Hypothetical protein | 107.908 |
| Enriched in eggs | |||
| FN317800 | CAX73529.1 | Glutenin high molecular weight subunit DX5 | 1794.846 |
| FN319280 | CAX75008.1 | Tetraspanin 22 | 1769.270 |
| FN322023.1 | CAX77751.1 | Histidine-rich glycoprotein | 1656.913 |
| FN324495.1 | CAX80219.1 | Hypothetical protein | 1549.720 |
| FN326817 | CAX82541.1 | Histidine-rich glycoprotein | 1523.735 |
| FN317759.1 | CAX73488.1 | Similar to venom allergen-like (VAL) 25 protein | 1062.695 |
| FN324480.1 | CAX80126.1 | Hypothetical protein | 938.553 |
| FN321785 | CAX77509.1 | Ribonuclease T2 | 850.487 |
| FN321171.1 | CAX76897.1 | Hypothetical protein | 831.194 |
| FN324498.1 | CAX80222.1 | Hypothetical protein | 776.801 |
| FN319117.1 | CAX74843.1 | CIA30 domain containing protein | 665.147 |
| FN317754 | CAX73483.1 | Tetraspanin | 663.055 |
| FN322724.1 | CAX78439.1 | Peptidase inhibitor 16 | 651.579 |
| FN319142 | CAX74870.1 | Hypothetical protein | 628.202 |
| FN320551 | CAX76277.1 | Egg protein CP1531 | 592.491 |
| FN326664 | CAX82388.1 | Hypothetical protein | 577.505 |
| AY816014.1 | AAW27746.1 | Ribonuclease S-4 | 534.668 |
| FN321764.1 | CAX77484.1 | Cell wall integrity and stress response component 1 | 488.342 |
| FN326758 | CAX82480.1 | Hypothetical protein | 484.608 |
| FN317167 | CAX72898.1 | Hypothetical protein | 481.352 |
| FN319216.1 | CAX74944.1 | Hypothetical protein | 453.890 |
| FN320451 | CAX76177.1 | GLIPR1-like protein 1/venom allergen-like protein 5 | 422.820 |
| FN317231 | CAX72962.1 | GLIPR1-like protein 1/venom allergen-like protein 5 | 417.438 |
| FN326877 | CAX82601.1 | Hypothetical protein | 416.455 |
| FN330952.1 | CAX83183.1 | Ribonuclease Oy | 414.347 |
