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Table 2 Flea count data for primary cats in the fluralaner topical and fipronil/(S)-methoprene groups. No efficacy comparison was performed at V1 and no primary cats had 90% reduction or were flea-free at V1

From: A randomized, blinded, controlled USA field study to assess the use of fluralaner topical solution in controlling feline flea infestations

  Visit 1
(enrollment)
Visit 2
(Week 4, Day 28)
Visit 3
(Week 8, Day 56)
Visit 4
(Week 12, Day 84)
Number of primary cats
Fluralaner topical solution 116 114 106 105
Fipronil/(S)-methoprene spot-on solution 45 40 38 34
Arithmetic mean flea count (95% CI)
Fluralaner topical solution 47.8 (36.5–59.1) 0.7 (0.1–1.3) 0.4 (0.0–1.0) 0.6 (0.3–0.9)
Fipronil/(S)-methoprene spot-on solution 83.0 (24.7–141.2) 37.1 (14.5–59.7) 28.6 (14.3–42.9) 20.4 (10.0–30.8)
P-value for comparisona t (158.9) = -1.71, P = 0.0899 t (160.5) = -5.17, P < 0.0001 t (155.8) = -6.35, P < 0.0001 t (148.4) = -6.88, P < 0.0001
% efficacy (reduction from baseline) based on arithmetic means
Fluralaner topical solution na 98.6 99.1 98.7
P-value for comparison to baselinea na t (158.5) = 5.51, P < 0.0001 t (159.2) = 4.74, P < 0.0001 t (159.1) = 4.50, P < 0.0001
Fipronil/(S)-methoprene spot-on solution na 55.2 65.5 75.4
P-value for comparison to baselinea na t (160.4) = 3.49, P = 0.0006 t (159.9) = 3.50, P = 0.0006 t (159.6) = 3.75, P = 0.0002
Geometric mean flea count (95% CI)
Fluralaner topical solution 28.0 (23.2–33.8) 0.2 (0.1–0.4) 0.1 (0.0–0.2) 0.3 (0.2–0.4)
Fipronil/(S)-methoprene spot-on solution 28.0 (19.2–40.9) 15.0 (9.5–23.3) 9.4 (5.2–16.4) 6.8 (3.6–12.1)
P-value for comparisona t (139.9) = 0.07, P = 0.9474 t (139.7) = -17.56, P < 0.0001 t (144.7) = -13.23, P < 0.0001 t (139.3) = -10.80, P < 0.0001
% efficacy (reduction from baseline) based on geometric means
Fluralaner topical solution na 99.1 99.5 99.0
P-value for comparison to baselinea na t (151.9) = 32.41, P < 0.0001 t (150.8) = 30.60, P < 0.0001 t (147.1) = 29.81, P < 0.0001
Fipronil/(S)-methoprene spot-on solution na 46.5 66.6 75.8
P-value for comparison to baselinea na t (159.3) = 3.96, P = 0.0001 t (155.9) = 6.11, P < 0.0001 t (158.4) = 7.68, P < 0.0001
% of primary cats with at least 90% reduction from baseline flea count
Fluralaner topical solution na 93.9 96.2 93.3
Fipronil/(S)-methoprene spot-on solution na 10.0 31.6 38.2
P-value for comparisonb na Z = -10.17, P < 0.0001 Z = -7.26, P < 0.0001 Z = -6.96, P < 0.0001
% of flea-free primary cats
Fluralaner topical solution na 80.7 88.7 80.0
Fipronil/(S)-methoprene spot-on solution na 5.0 21.1 23.5
P-value for comparisonb na Z = -8.45, P < 0.0001 Z = -7.87, P < 0.0001 Z = -6.05, P < 0.0001
  1. Abbreviation: na value or calculation is not applicable
  2. a P-value for comparison of model least squares means parameter estimates
  3. b P-value for comparison of percentages using non-parametric asymptotic approach and Standardized Statistic