Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis

Table 3 Similarity ratios produced by pairwise alignment of LmlRab with Leishmania strains ortholog sequences

Leishmania strain	Chromosome/Gene ID	Genomic coordinates	Product^a	Similarity %		Similarity %		Similarity %
				L. major HV P25 (Tunisia)		N-ter		C-Ter
				AY962589.1		AY962589.1		AY962589.1
				N (%)	P (%)	N (%)	P (%)	N (%)	P (%)
L. major Friedlin	LmjF.31.0860	315900–317732 (–)	ras-like small GTPases, putative	99.60	98.90	99.5	98.9	99.6	98.8
L. major strain SD 75.1	JH605118.1	298109–299941 (–)	not yet annotated	99.60	98.90	99.5	98.8	99.5	98.9
L. major strain LV39c5	KB217892.1	1129713–1131545	not yet annotated	99.50	98.70	99.5	98.9	99.6	98.6
L. infantum JPCM5	LinJ.31.0890	322703–324532 (–)	ras-like small GTPases, putative	94.40	91.00	94.00	94.5	93.0	89.3
L. donovani BPK282A1	LdBPK_310890.1	329426–331255 (–)	not yet annotated	93.30	90.80	94.2	95.1	92.6	88.6
L. tropica L590	KE147396.1	108776–110605 (–)	not yet annotated	94.30	90.70	90.4	94.0	87.1	89.0
L. tropica L590	KE147396.1	100399–102228 (–)	not yet annotated	94.30	90.70	95.4	95.1	93.6	89.3
L. mexicana U1103	LmxM.30.0860	324259–326091 (–)	ras-like small GTPases, putative	93.10	90.50	96.2	90.2	88.0	79.4
L. amazonensis M2269	KE390271.1	700–2532	not yet annotated	94.20	90.50	90.4	89.6	87.1	78.3
L. aethiopica L147	AUMB01001544.1	10483–12315	not yet annotated	88.70	82.70	95.4	93.4	93.8	89.5
L. aethiopica L147	AUMB01001560.1	101–1933	not yet annotated	88.10	81.70	95.4	93.4	93.8	89.5
L. braziliensis M2904	LbrM.31.1020	360616–362445 (–)	ras-like small GTPases, putative	74.50	63.80	78.1	74.3	72.9	59.3
L. braziliensis M2903	LbrM2903_31_1140	408882–410711 (–)	ras-like small GTPases, putative	74.40	63.70	78.3	74.3	72.9	59.3

^aAccording to TriTrypDB release 24 (15/04/2015) www.tritrypdb.org
For each of the selected Leishmania strains, the chromosome (or gene ID if chromosome were not assembled yet), the genomic coordinates and the gene product as described in the TriTrypDB server (Release 24 of 15/04/2015) is provided. Similarity ratios were drawn from pairwise alignments of both nucleic (columns noted “N”) and peptidic (columns noted “P”) sequences, regarding the entire gene sequence (column named “L. major HV P25 (Tunisia)”), the so called N-terminal region ranging from residue 1 to 183 (column named “N Ter”) and the so called C-terminal region ranging from residue 184 to 611 (column named “C Ter”)

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