Canine β-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs

Parasites & Vectors

Table 1 Association between genetic polymorphisms in β-defensin-1 and with Leishmania infantum in dogs from Sobral, Brazil

SNP	Variation ID	Position^a	Alleles	HWE	Possible genotype	Total frequency (n = 190)	Frequency in cases (n = 70)	Frequency in controls (n = 120)	Odds ratio (95% CI)	Logistic regression (P-value)
SNP1	rs852527703	58881447	C/T	0.14	T/T	0.23	0.19	0.25	0.51 (0.22–1.15)	0.17
					C/T	0.44	0.40	0.47	0.59 (0.30–1.15)
					C/C	0.33	0.41	0.28	1.00
SNP2	rs852380685	58881356	C/T	0.14	T/T	0.23	0.19	0.25	0.51 (0.22–1.15)	0.17
					C/T	0.44	0.40	0.47	0.59 (0.30–1.15)
					C/C	0.33	0.41	0.28	1.00
SNP3	rs850814192	58881297	A/G	0.59	G/G	0.51	0.49	0.52	1.00	0.73
					A/G	0.42	0.43	0.42	1.11 (0.60–2.06)
					A/A	0.07	0.09	0.06	1.59 (0.49–5.10)
SNP4	rs852670798	58881294	A/C	0.77	C/C	0.30	0.31	0.29	1.00	0.87
					A/C	0.51	0.49	0.52	0.86 (0.44–1.69)
					A/A	0.19	0.20	0.18	1.01 (0.43–2.38)
SNP5	rs852439766	58881277	C/T	0.082	T/T	0.25	0.26	0.25	1.00	0.89
					C/T	0.56	0.54	0.57	0.92 (0.45–1.86)
					C/C	0.18	0.20	0.18	1.11 (0.45–2.72)
SNP6	rs850643698	58881159	A/G	0.77	G/G	0.19	0.20	0.18	1.01 (0.43–2.38)	0.87
					A/G	0.51	0.49	0.52	0.86 (0.44–1.69)
					A/A	0.30	0.31	0.29	1.00
SNP7	rs853079810	58881122	A/G	0.19	G/G	0.25	0.26	0.25	1.00	0.91
					A/G	0.55	0.53	0.56	0.92 (0.45–1.87)
					A/A	0.20	0.21	0.19	1.09 (0.45–2.61)
SNP8	rs851268228	58881093	C/T	1	T/T	0.08	0.10	0.07	1.57 (0.53–4.71)	0.72
					C/T	0.41	0.40	0.41	1.03 (0.55–1.92)
					C/C	0.52	0.50	0.52	1.00
SNP9	rs850702571	58881081	A/G	0.24	G/G	0.48	0.50	0.48	1.00	0.88
					A/G	0.39	0.37	0.41	0.86 (0.46–1.63)
					A/A	0.12	0.13	0.12	1.05 (0.41–2.67)

^aPosition in the reference sequence of canine chromosome 16 (accession number: NC_006598.3)
Abbreviations: SNPs single nucleotide polymorphisms, HWE Hardy-Weinberg equilibrium

ISSN: 1756-3305