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Table 1 Natural selection tests on pvama1 I-II among P. vivax populations of different geographic origins

From: Temporal genetic changes in Plasmodium vivax apical membrane antigen 1 over 19 years of transmission in southern Mexico

Country Polymorphic changes within P. vivax populations dN-dS valuea P Fixed changes between speciesb McDonald-Kreitman (NI) Fisher’s exact test (P-value)
Synonymous Nonsynonymous Synonymous Nonsynonymous
SMX 1 15 1.510 0.13 53 25 31.800 < 0.000001
VNZ 2 9 0.821 0.41 54 28 8.679 0.00591
IR 4 24 0.844 0.40 51 24 12.750 < 0.000001
SLK 2 21 2.154 0.03 53 24 23.188 < 0.000001
IND 7 23 1.012 0.31 53 24 7.253 0.00002
PNG 4 15 1.725 0.09 51 24 12.750 0.00001
THL 7 19 -0.071 0.94 50 21 8.333 0.00002
SK 10 16 -0.425 0.67 51 25 3.264 0.01934
Total 20 44 0.836 0.40 45 20 4.950 0.00002
  1. a dN-dS, the difference between the rate of nonsynonymous and synonymous mutations
  2. b Plasmodium cynomolgi was used as the outgroup species (GenBank: X66099.1)
  3. Abbreviations: NI Neutrality Index (significance at 95%), SMX southern Mexico, VEN Venezuela, IR Iran, SLK Sri Lanka, IND India, PNG Papua New Guinea, THL Thailand, SK South Korea