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Table 2 Toxicity assessment. Compounds a-15 and a-17 were tested for toxic effects on a human neonatal foreskin fibroblast (NFF) cell line; tolfenpyrad was included as a reference control. Selectivity indices of these compounds on the motility of exsheathed third- and fourth-stage larvae (at 72 h) (xL3s and L4s) and the development of L4s (at 7 days) were calculated using a recognised formula [16]

From: Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Compound IC50 (μM) for NFF cells Selectivity index (SI) for H. contortus
xL3 motility L4 motility L4 development
a-15 66.72 ± 10.04 1.20 2.54 16.81
a-17 72.15 ± 1.61 1.40 4.63 21.10
Tolfenpyrad > 50 > 16.40 > 1666.70 > 625