Table 2 Toxicity assessment. Compounds a-15 and a-17 were tested for toxic effects on a human neonatal foreskin fibroblast (NFF) cell line; tolfenpyrad was included as a reference control. Selectivity indices of these compounds on the motility of exsheathed third- and fourth-stage larvae (at 72 h) (xL3s and L4s) and the development of L4s (at 7 days) were calculated using a recognised formula [16]
Compound | IC50 (μM) for NFF cells | Selectivity index (SI) for H. contortus | ||
|---|---|---|---|---|
xL3 motility | L4 motility | L4 development | ||
a-15 | 66.72 ± 10.04 | 1.20 | 2.54 | 16.81 |
a-17 | 72.15 ± 1.61 | 1.40 | 4.63 | 21.10 |
Tolfenpyrad | > 50 | > 16.40 | > 1666.70 | > 625 |