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Table 3 IC50 values (± SD) of compounds with reported activity against S. mansoni generated with XTT viability assay compared to values obtained by microscopy analysis

From: A high-throughput colorimetric assay for detection of Schistosoma mansoni viability based on the tetrazolium salt XTT

Compound IC50 (μM)
XTT Assay Microscopy
Mefloquine 8.9 ± 0.6 10.2 ± 0.2
Ivermectin 2.2 ± 0.1 2.3 ± 0.1
JQ1 21.2 ± 2.9 19.6 ± 0.3
Praziquantel ~ 588a ~ 472a
Curcumin 13.0 ± 5.7 14.7 ± 0.3
Amphotericin 2.4 ± 0.1 0.2 ± 0.04
  1. aSD not determined