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Table 3 IC50 values (± SD) of compounds with reported activity against S. mansoni generated with XTT viability assay compared to values obtained by microscopy analysis

From: A high-throughput colorimetric assay for detection of Schistosoma mansoni viability based on the tetrazolium salt XTT

Compound

IC50 (μM)

XTT Assay

Microscopy

Mefloquine

8.9 ± 0.6

10.2 ± 0.2

Ivermectin

2.2 ± 0.1

2.3 ± 0.1

JQ1

21.2 ± 2.9

19.6 ± 0.3

Praziquantel

~ 588a

~ 472a

Curcumin

13.0 ± 5.7

14.7 ± 0.3

Amphotericin

2.4 ± 0.1

0.2 ± 0.04

  1. aSD not determined