Systemic insecticide treatment of the canine reservoir of Trypanosoma cruzi induces high levels of lethality in Triatoma infestans, a principal vector of Chagas disease

Table 1 Properties of candidate systemic anti-parasitic compounds for canine feed-through assays

Commercial name (Company)	Active compound (Family)	Dose (mg/kg)^a	Mode of action	Safety (mg/kg)	Activity period^a	Reference
Comfortis® (Elanco Animal Health)	Spinosad (Spinosyns)	45–70	Binds nicotinic acetylcholine receptors	Oral >3600	4 weeks	[30, 34, 40,41,42,43]
Bravecto® (Merck Animal Health)	Fluralaner (Isoxazolines)	25	Non-competitive GABA receptor antagonist	Oral >2000	12 weeks	[14, 18, 19, 27, 37, 44]
NexGard® (Merial)	Afoxolaner (Isoxazolines)	2.5	Non-competitive GABA receptor antagonist	Oral >1000	5 weeks	[24, 45,46,47,48]

ISSN: 1756-3305