Fig. 5
From: Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis
Pathway analysis of the differential metabolites during acute and chronic infection. Metabolite features with putative identification were analyzed using MetaboAnalyst for potential impact on metabolic pathways in the acute phase a and chronic phase b. Small P-value and large pathway impact factor indicate that the pathway is greatly influenced, such as arachidonic acid metabolism pathway, which was highly impacted during acute and chronic infection. c A schematic illustration of the arachidonic acid metabolism pathway during chronic infection. Red and black circles represent upregulated and unaltered metabolites, respectively. As shown, arachidonic acid (AA), leukotriene A4 (LTA4), 14,15-HETE, and 15-deoxy-Δ12,14-PGJ2 were upregulated