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Table 1 IC50 and IC90 values of PZQ, R-PZQ, S-PZQ enantiomers and trans-4-OH-PZQ against adult worms of S. haematobium

From: In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium

  IC50 at 4 h (μg/ml) r-value IC50 at 72 h (μg/ml) r-value IC90 at 72 h (μg/ml) r-value Eudysmic ratio
PZQ 0.03 0.978 0.03 0.965 0.09 0.978 501
R-PZQ 0.007 0.803 0.01 0.940 0.03 0.940  
S-PZQ 3.51 0.925 3.40 0.923 5.98 0.923
Trans-4-OH-PZQ 1.47 0.891 1.47 0.891 3.31 0.891