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Table 1 Geometric (arithmetic) mean live A. cajennense counts and ranges for placebo and treated dogs and percent efficacy relative to placebo for dogs treated once orally with sarolaner chewable tables at 2 mg/kg on day 0 for evaluations performed at 48 h after treatment and post-treatment re-infestations

From: Efficacy of sarolaner (Simparic™) against induced infestations of Amblyomma cajennense on dogs

  

Placebo

Sarolaner

% Efficacy

 

Day

Mean

Range

Dogs with ticks

Mean

Range

Dogs with ticks

 

48 h post-treatment

2

47.0 (49.2)

27–73

0/10

0.0a (0.0)

0–0

0/10

100

48 h post-infestation

7

50.5 (51.8)

32–68

0/10

0.0a (0.0)

0–0

0/10

100

14

48.2 (50.6)

28–73

0/10

0.0a (0.0)

0–0

0/10

100

21

54.0 (56.2)

34–83

0/10

0.1a (0.1)

0–1

1/10

9.99

28

53.2 (56.4)

27–80

0/10

0.1a (0.2)

0–1

2/10

7.99

35

51.5 (54.8)

24–78

0/10

0.2a (0.3)

0–1

3/10

6.99

  1. aGeometric mean live tick count significantly lower than placebo (P < 0.0001)