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Table 1 Protease inhibition assays

From: Characterization of a secreted cystatin of the parasitic nematode Haemonchus contortus and its immune-modulatory effect on goat monocytes

Enzyme

Enzyme concentration (nM)

HCcyst-3 (nM)

 
  

IC50

95% CI

Papain

150

208.7

198.7–219.2

Cathepsin L

50

18.5

17.6–19.5

Cathepsin B

50

121.6

109.2–135.4

Caspase 1

50

NI

 
  1. Abbreviation: CI, confidence interval; NI, no inhibition
  2. The concentration of HCcyst-3 at which 50% of the proteolytic enzymes’ activity is inhibited (IC50)
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Parasites & Vectors

ISSN: 1756-3305

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