Genetic profiles of ten Dirofilaria immitis isolates susceptible or resistant to macrocyclic lactone heartworm preventives

Table 1 Dirofilaria immitis isolates used for MiSeq sequencing

Isolate	Efficacy percentage reduction^a (%)	Phenotype	Origin of the Isolate in USA
ZoeMI	100	Susceptible	MI
ZoeGCFL	100	Susceptible	Fort Myers, FL.
ZoeAL	100	Susceptible	Westover, AL
ZoeKY	100	Susceptible	Salyersville, KY
ZoeMP3	100	Susceptible^b	TRS Lab, GA
ZoeMO^c	82	Resistant	Pittsfield, IL/Keytesville, MO/Stanwood, MI
ZoeAMAL	62	Resistant	Westover, AL
ZoeLA	54	Resistant	Ellis, AR/Slaughter, LA
ZoeJYD-34	19	Resistant	Pittsfield, IL/Keytesville, MO/Stanwood, MI
Metairie^d	N/A	Resistant	Metairie, LA and spent time in MS

^aInformation related to moxidectin phenotypic response is from McTier et al. [15]. The efficacy study was based on 3 μg/kg of oral moxidectin. Efficacy studies described in McTier et al. [15]
^bPredominantly susceptible.
^cRelative of ZoeJYD-34
^dInformation on the resistant Metairie isolate is available in Maclean et al. [16]

ISSN: 1756-3305