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Table 2 Study design for nine studies using nine different isolates of D. immitis used to assess the efficacy of 3 μg/kg of oral moxidectin in dogs

From: Efficacy of oral moxidectin against susceptible and resistant isolates of Dirofilaria immitis in dogs

Study No. of dogs/Gpa D. immitis isolate Treatmentb Dosage (μg/kg) Day of inoculation Days of treatment (oral) Day of necropsy (PI)
1 8 Michigan Moxidectin 3 −30 0 116 (146)
2 8 MP3 Moxidectin 3 −30 0 120 (150)
3 6 ZoeKY Moxidectin 3 −30 0 117 (147)
4 3 GCFL Moxidectin 3 −28 0 120 (148)
5 6 ZoeAL Moxidectin 3 −28 0 120 (148)
6 8 JYD-34 Moxidectin 3 −30 0 122 (152)
6 8 JYD-34 Moxidectin 3 −30 0, 30 and 60 122 (152)
7 6 ZoeMO Moxidectin 3 −30 0 117 (147)
8 6 ZoeLA Moxidectin 3 −30 0 118 (148)
9 3 AMAL Moxidectin 3 −28 0 120 (148)
  1. aMatched placebo control group was included in each study
  2. bProHeart® tablets shaved to deliver the exact dose