Shifting the paradigm in Dirofilaria immitis prevention: blocking transmission from mosquitoes to dogs using repellents/insecticides and macrocyclic lactone prevention as part of a multimodal approach

Table 7 Worm counts in dogs 148 to 149 days after the last infection by exposure to Aedes aegypti mosquitoes previously infected with Dirofilaria immitis (JYD-34 strain) 21 and 28 days after DPP administration

Groups	1 Control		2 DPP^a		3 MBO^b		4 DPP + MBO
Worms^c	Male	Female	Male	Female	Male	Female	Male	Female
Dogs
1	8	13	3	4	3	4	0	0
2	12	19	1	2	14	12	0	0
3	24	20	0	0	3	4	0	0
4	21	16	0	2	19	20	0	0
5	18	19	0	0	9	5	0	0
6	32	34	0	0	7	2	0	0
7	27	25	0	0	6	3	0	0
8	16	24	0	0	13	13	0	0
Average/dog	19.8	21.3	0.5	1.0	9.3	7.9	0	0
	41.0		1.5		17.1		0
P value	P < 0.0001^d				P < 0.0001
Preventive efficacy (%)	–		96.3		58.2		100

^a DPP dinotefuran + permethrin + pyriproxyfen
^b MBO milbemycin oxime
^cAll worms were live at the time of necropsy and found in the circulatory system
^dSignificant difference between Groups 1 and 2 and between Groups 3 and 4

ISSN: 1756-3305