Table 1 Results of flea infestations at 4 h post-treatment and 4 h after weekly infestations in Study 1

Control

Arithmetic mean ± SD

60.9 ± 12.5

76.0 ± 9.8

78.6 ± 13.1

71.0 ± 6.4

67.3 ± 5.6

73.1 ± 12.3

Geometric mean

59.9

75.4

77.7

70.8

67.1

72.3

Lotilaner

Arithmetic mean ± SD

26.4 ± 33.8

0.1 ± 0.4

0.0 ± 0.0

1.0 ± 1.3

0.8 ± 1.2

2.1 ± 1.7

Efficacy (%)

56.7

99.8

100.0

98.6

98.9

97.1

Geometric mean

6.1

0.1

0.0

0.7

0.5

1.6

Efficacy (%)

89.9

99.9

100

99.0

99.3

97.8

t ₍₅₎ = 3.4, P = 0.0194

t ₍₅₎ = 55.0, P < 0.0001

t ₍₅₎ = 91.5, P < 0.0001

t ₍₅₎ = 21.8, P < 0.0001

t ₍₅₎ = 18.5, P < 0.0001

t ₍₅₎ = 14.9, P < 0.0001