Table 2 Results of flea infestations at 6 h post-treatment and 6 h after weekly infestations in Study 2

Control

Arithmetic mean ± SD

76.6 ± 20.1

78.6 ± 8.7

88.9 ± 12.2

95.4 ± 5.6

94.5 ± 7.6

93.8 ± 7.9

Geometric mean

74.3

78.2

88.1

95.2

94.2

93.5

Lotilaner

Arithmetic mean ± SD

2.6 ± 7.0

0.1 ± 0.4

0.0 ± 0.0

3.6 ± 10.3

1.6 ± 3.1

1.8 ± 2.4

Efficacy (%)

96.6

99.8

100

96.2

98.3

98.1

Geometric mean

0.6

0.1

0.0

0.5

0.8

1.0

Efficacy (%)

99.2

99.9

100

99.4

99.1

98.9

t ₍₇₎ = 11.4, P < 0.0001

t ₍₇₎ = 45.0, P < 0.0001

t ₍₇₎ = 88.4, P < 0.0001

t ₍₇₎ = 9.7, P < 0.0001

t ₍₇₎ = 14.3, P < 0.0001

t ₍₇₎ = 13.6, P < 0.0001