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Table 1 Range of lotilaner dose rates administered to each of the study groups

From: Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™)

  Day of dosing
1 29 57 85 113 141 169 197
43 mg/kg (1×)
 Male 44.3–59.5 48.2–57.7 43.3–46.9 43.3–46.5 42.5–45.9 39.5–46.6 40.2–45.3 42.3–44.4
 Female 54.1–65.0 44.1–70.3 43.8–51.9 41.2–54.4 40.7–47.9 43.3–46.1 40.9–45.9 45.6–47.5
129 mg/kg (3×)
 Male 123.4–137.8 123.6–130.4 123.6–130.8 128.0–133.5 125.8–132.8 125.8–132.0 129.3–132.7 129.0–131.4
 Female 131.6–151.0 119.7–144.2 125.0–136.4 131.6–137.2 126.1–130.2 125.0–132.4 127.2–132.9 129.5–136.1
215 mg/kg (5×)
 Male 209.3–226.3 214.3–225.0 206.3–220.1 218.0–228.0 211.5–218.8 213.0–217.5 214.3–220.1 216.6–220.4
 Female 203.0–220.6 209.3–225.0 208.3–220.6 214.3–227.3 211.6–220.1 209.6–212.8 213.5–219.7 217.0–220.9