Table 1 Range of lotilaner dose rates administered to each of the study groups
Day of dosing | ||||||||
|---|---|---|---|---|---|---|---|---|
1 | 29 | 57 | 85 | 113 | 141 | 169 | 197 | |
43 mg/kg (1×) | ||||||||
Male | 44.3–59.5 | 48.2–57.7 | 43.3–46.9 | 43.3–46.5 | 42.5–45.9 | 39.5–46.6 | 40.2–45.3 | 42.3–44.4 |
Female | 54.1–65.0 | 44.1–70.3 | 43.8–51.9 | 41.2–54.4 | 40.7–47.9 | 43.3–46.1 | 40.9–45.9 | 45.6–47.5 |
129 mg/kg (3×) | ||||||||
Male | 123.4–137.8 | 123.6–130.4 | 123.6–130.8 | 128.0–133.5 | 125.8–132.8 | 125.8–132.0 | 129.3–132.7 | 129.0–131.4 |
Female | 131.6–151.0 | 119.7–144.2 | 125.0–136.4 | 131.6–137.2 | 126.1–130.2 | 125.0–132.4 | 127.2–132.9 | 129.5–136.1 |
215 mg/kg (5×) | ||||||||
Male | 209.3–226.3 | 214.3–225.0 | 206.3–220.1 | 218.0–228.0 | 211.5–218.8 | 213.0–217.5 | 214.3–220.1 | 216.6–220.4 |
Female | 203.0–220.6 | 209.3–225.0 | 208.3–220.6 | 214.3–227.3 | 211.6–220.1 | 209.6–212.8 | 213.5–219.7 | 217.0–220.9 |