Two randomized, controlled studies to assess the efficacy and safety of lotilaner (Credelio™) in preventing Dermacentor reticulatus transmission of Babesia canis to dogs

Table 2 Geometric (arithmetic) mean counts of live Dermacentor reticulatus and percent efficacy

Day	Untreated control		Lotilaner			Comparison
Day	Mean	Range	Mean	Range	Efficacy (%)
Study 1
4	22.2 (22.4)	18–29	0.2 (0.3)	0–1	99.1 (98.7)	t ₍₁₄₎ = 24.07, P < 0.0001
9	37.6 (39.1)	23–52	0.2 (0.3)	0–2	99.5 (99.2)	t ₍₁₄₎ = 20.16, P < 0.0001
16	13.3 (14.3)	5–19	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 18.54, P < 0.0001
23	25.1 (32.5)	4–87	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 11.26, P < 0.0001
30	23.4 (25.1)	12–41	0.0 (0.0)	0–0	100 (100)	t ₍₁₄₎ = 21.71, P < 0.0001
Study 2
34	23.7 (24.5)	15–36	0.0 (0.0)	0–0	100 (100)	t ₍₁₀₎ = 28.45, P < 0.0001

ISSN: 1756-3305