Skip to main content

Table 2 Mean ± standard deviation pharmacokinetic parameters of lotilaner in adult beagle dogs after either single administration at a target dose of 20 mg/kg orally to fasted dogs, orally to fed dogs, or at a target dose of 3.0 mg/kg intravenously

From: The intravenous and oral pharmacokinetics of lotilaner in dogs

Parameter Intravenous, 3 mg/kg (n = 8) Oral, fed 20 mg/kg (n = 12) Oral, fasted 20 mg/kg (n = 6)
Actual doses (mg/kg) 3.08–3.24 20.09–24.67 20.16–24.62
Tmax (hours) na 2 (range: 1–24) 4 (range: 2–24)
Cmax (ng/ml) na 4011 ± 990 1454 ± 849
AUClast (day*ng/ml) 10,976 ± 1381 62,840 ± 17,346 18,592 ± 16,632
AUCinf (day*ng/ml) 17,844 ± 1937 118,600 ± 42,287 40,886 ± 31,915
Cmax (dose normalizeda) (ng/ml) na 179.2 ± 43.5 65.4 ± 35.7
AUClast (dose normalizeda) (day*ng/ml) 3436 ± 430 2806 ± 801 837 ± 731
AUCinf (dose normalizeda) (day*ng/ml) 5586 ± 666 5297 ± 1921 1840 ± 1406
T1/2z (day) 24.6 ± 5.9 30.7 ± 10.0 38.8 ± 11.2
MRT (day) 36.0 ± 8.5 45.3 ± 13.9 56.9 ± 14.8
CL (l/kg/day) 0.18 ± 0.02 na na
Vz (l/kg) 6.35 ± 1.27 na na
Vss (l/kg) 6.45 ± 1.26 na na
Bioavailability (F%) na 81.7 24.3
  1. aDose-normalized to 1 mg/kg
  2. All values (Mean and standard deviation) are based on geometric summary statistics (corresponding to summary statistics of log transformed values and then back-transformed), except for Tmax which is based on the median