Table 2 Mean ± standard deviation pharmacokinetic parameters of lotilaner in adult beagle dogs after either single administration at a target dose of 20 mg/kg orally to fasted dogs, orally to fed dogs, or at a target dose of 3.0 mg/kg intravenously
From: The intravenous and oral pharmacokinetics of lotilaner in dogs
Parameter | Intravenous, 3 mg/kg (n = 8) | Oral, fed 20 mg/kg (n = 12) | Oral, fasted 20 mg/kg (n = 6) |
|---|---|---|---|
Actual doses (mg/kg) | 3.08–3.24 | 20.09–24.67 | 20.16–24.62 |
Tmax (hours) | na | 2 (range: 1–24) | 4 (range: 2–24) |
Cmax (ng/ml) | na | 4011 ± 990 | 1454 ± 849 |
AUClast (day*ng/ml) | 10,976 ± 1381 | 62,840 ± 17,346 | 18,592 ± 16,632 |
AUCinf (day*ng/ml) | 17,844 ± 1937 | 118,600 ± 42,287 | 40,886 ± 31,915 |
Cmax (dose normalizeda) (ng/ml) | na | 179.2 ± 43.5 | 65.4 ± 35.7 |
AUClast (dose normalizeda) (day*ng/ml) | 3436 ± 430 | 2806 ± 801 | 837 ± 731 |
AUCinf (dose normalizeda) (day*ng/ml) | 5586 ± 666 | 5297 ± 1921 | 1840 ± 1406 |
T1/2z (day) | 24.6 ± 5.9 | 30.7 ± 10.0 | 38.8 ± 11.2 |
MRT (day) | 36.0 ± 8.5 | 45.3 ± 13.9 | 56.9 ± 14.8 |
CL (l/kg/day) | 0.18 ± 0.02 | na | na |
Vz (l/kg) | 6.35 ± 1.27 | na | na |
Vss (l/kg) | 6.45 ± 1.26 | na | na |
Bioavailability (F%) | na | 81.7 | 24.3 |