Table 3 Comparisons between fed and fasted groups following oral administration of lotilaner at 20 mg/kg (Study 2)
From: The intravenous and oral pharmacokinetics of lotilaner in dogs
Parameter | Ratio (fasted to fed) | 90% CI | t-value | P-valuea |
|---|---|---|---|---|
T1/2z | 1.263 | 0.983–1.624 | t (23) = -1.59 | 0.1244 |
MRT | 1.256 | 0.991–1.591 | t (23) = -1.65 | 0.1128 |
Cmax (dose normalized) | 0.365 | 0.265–0.502 | t (16) = 5.51 | < 0.0001 |
AUClast (dose normalized) | 0.298 | 0.201–0.441 | t (23) = 5.29 | < 0.0001 |
AUCinf (dose normalized) | 0.347 | 0.238–0.507 | t (23) = 4.80 | < 0.0001 |
Bioavailability | 0.298 | 0.201–0.441 | t (23) = 5.29 | < 0.0001 |