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Table 3 Comparisons between fed and fasted groups following oral administration of lotilaner at 20 mg/kg (Study 2)

From: The intravenous and oral pharmacokinetics of lotilaner in dogs

Parameter Ratio (fasted to fed) 90% CI t-value P-valuea
T1/2z 1.263 0.983–1.624 t (23) = -1.59 0.1244
MRT 1.256 0.991–1.591 t (23) = -1.65 0.1128
Cmax (dose normalized) 0.365 0.265–0.502 t (16) = 5.51 < 0.0001
AUClast (dose normalized) 0.298 0.201–0.441 t (23) = 5.29 < 0.0001
AUCinf (dose normalized) 0.347 0.238–0.507 t (23) = 4.80 < 0.0001
Bioavailability 0.298 0.201–0.441 t (23) = 5.29 < 0.0001
  1. a P-values in bold denote significance