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Table 2 Reported performance characteristics of selected commercial heartworm antigen tests used in dogs

From: Prime detection of Dirofilaria immitis: understanding the influence of blocked antigen on heartworm test performance

Test % Sensitivity (number of live adult female heartworms) % Specificity Heartworm positive/total tested Reference
DiroCHEK® 85.7 (1), 95 (2), 100 (≥ 3) 100 108/208b, c, d, e [1]
PetChek® HTWM PF 76.2 (1), 85 (2), 100 (≥ 3) 100
Solo Step® CHBatch 71.4 (1), 95 (2), 96.5 (≥ 3) 100
Solo Step® CH 76.2 (1), 95 (2), 96.5 (≥ 3) 100
ICT Gold® HW 61.9 (1), 85 (2), 93 (≥ 3) 100
SNAP® Heartworm PF 76.2 (1), 85 (2), 100 (≥ 3) 100
Witness® HW 71.4 (1), 90 (2), 94.7 (≥ 3) 100
AbboScreen™ 71.4 (1), 100 (2), 93 (≥ 3) 96
FILARIA IC (Italian) 76.2 (1), 85 (2), 100 (≥ 3) 100
Witness™ HW (Australian) 66.7 (1), 90 (2), 94.7 (≥ 3) 100
VetScan CHAT 78 97 208/240b, e [2]
SNAP® Heartworm RT 84 97
Solo Step® CH 79 97
PetChek® HTWM PF 45 (0a), 77 (1–2), 94 (≥ 3) 97 140/237e [10]
DiroCHEK® 40 (0a), 71 (1–2), 94 (≥ 3) 94
SNAP® Heartworm PF 35 (0a), 65 (1–2), 94 (≥ 3) 98
Solo Step® CH 35 (0a), 56 (1–2), 90 (≥ 3) 98
AbboScreen 30 (0a), 46 (1–2), 84 (≥ 3) 96
VetScan VS2 33 100 40/90e [11]
SNAP® Heartworm RT 90 100
SNAP® Heartworm RT 90.9 98.8 84/150b, f [37]
Witness® Heartworm 97.0 96.4
Filarchek 97.6 100 41/107 [60]
VetScan 92 100 25/49e [61]
DiroCHEK® 100 (≥3) 100 NR [62]
Witness® Heartworm 97.7 99.3 134/285e, f [63]
  1. aNot infected or infected only with male, immature, or dead worms
  2. bHeartworm infection established naturally
  3. cHeartworm infection established by subcutaneous injection of third-stage larvae
  4. dHeartworm infection established by surgical transplantation
  5. eInfection verified by necropsy
  6. fInfection verified by comparison to DiroCHEK®