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Table 8 Nematodes known or suspected to induce false positive results in canine serum, plasma, or whole blood samples tested on heartworm antigen tests without heat pretreatment of samples

From: Prime detection of Dirofilaria immitis: understanding the influence of blocked antigen on heartworm test performance

Species of nematode

Dirofilaria immitis antigen detected (number positive/number tested)

Origin of samples tested

Reference

Angiostrongylus vasorum

0/16 to 8/16a

Domestic dogs experimentally infected with An. vasorum

[49]

Spirocerca lupi

2/19 to 14/48a

Domestic dogsc with confirmed esophageal spirocercosis, resided in area without autochthonous D. immitis

[50]

8/32

Domestic dogsc with confirmed esophageal spirocercosis; PCR negative for D. immitis microfilaria

Acanthocheilonema odendhali

15/15

California sea lions (Zalophus californianus) with microfilaria of A. odendhali

[51]

Dirofilaria ursi

6/10

North American brown bear (Ursus arctos) presumed infected based on geographic location (northern Canada)

[52]

Angiostrongylus vasorum

1/3 to 3/3a

Domestic dogsc naturally infected with An. vasorum confirmed by serum antigen test for An. vasorum and fecal; history of consistent heartworm preventive use

[53]

Dirofilaria repens

0/4 to 2/4a, b

Domestic dogsc naturally infected with D. repens as confirmed by microfilaria and subcutaneous nodules

[53]

  1. aResults varied depending on heartworm antigen assay used
  2. bWith heat pretreatment of samples, increased to 4/4
  3. cPet dogs, true heartworm status unknown