Fig. 4

PbA-infected mice show long-lasting impairment in memory-related task performance. Effect of a treated PbA 4 day-infection on the total distance travelled in open field training and test sessions (a) and on the Δ between the first and the third minute distance travelled (b); effect of PbA 4 day-infection on the time spent in each object in the training (c) and test (d) sessions on the novel object recognition task; and effect of treated PbA 4 day-infection on time spent in each arm in the training (e) and test (f) sessions in the Y-Maze task. Data were analysed by two-way ANOVA, followed by Tukey’s multiple range post-hoc test. *P < 0.05, **P < 0.01 and ***P < 0.001, comparing the training (OFT1) and test (OFT2) sessions; the familiar (FO) and the novel (NO) object recognition task; and the different arms in the Y-maze task (n = 22 animals/group, combining 2 experiments). See Methods for behavioural task description. Arm 1 (closed and open on training and test sessions, respectively), arms 2 and 3 (open). Abbreviations: Non-inf mice, uninfected and PBS treated mice; PbA-inf mice, infected and chloroquine treated mice