Fig. 3

Univariate analysis of fecal S100A12 concentrations and the influence of fecal score and breed size in apparently healthy puppies (n = 307). a Dogs with an abnormal fecal score had significantly higher fecal S100A12 concentrations than dogs with a normal fecal score (Wilcoxon rank-sum test: Z = 5.749, P < 0.0001). b Small breed dogs had significantly higher fecal S100A12 concentrations than dogs of large breed size (Wilcoxon rank-sum test: Z = 4.879, P < 0.0001). Boxes: interquartile range (IQR); vertical lines within boxes: medians; whiskers: determined by the outermost data points or values computed as (25th quartile: -1.5 × IQR) or (75th quartile: +1.5×IQR). *Significant difference at P < 0.05; ***significant difference at P < 0.0001