Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants

Parasites & Vectors

Table 2 Clinical characteristics of patients with dengue and chikungunya monoinfection compared to dengue-chikungunya coinfection

Patient number	Age	Infection status	T (°C)^a	Presence of rash and distribution	Severe arthralgia/Myalgia^b	Arthralgia at 30 days	Total leukocytes (×10³/ml)	Total lymphocytes (×10³/ml)	Total platelets (×10³/ml)
130	5 y	Coinfection	38.0	Generalized	Yes	No	11.6 ↑	0.8 ↓	167
137	8 y	Coinfection	39.0	Generalized	Yes	Yes	10.10	0.6 ↓	256
147	4 m	Coinfection	39.1	Generalized including palms and soles	Yes	No	14.9	4.6	245
151	20 y	Coinfection	39.7	Generalized	Yes	No	8.3	2.1	244
152	7 y	Coinfection	38.5	Generalized	No	No	3.7 ↓	1.1 ↓	202
155	21 m	Coinfection	38.3	Generalized	Yes	Yes	10.8	1.4 ↓	258
170	2 m	Coinfection	38.7	Generalized	Yes	No	6.2	1.5 ↓	326
178	2 m	Coinfection	39.0	Generalized	Yes	No	18.6 ↑	2.5 ↓	313
180	3 m	Coinfection	39.2	Generalized	Yes	No	5.1 ↓	3.2 ↓	182
150	5 y	Dengue	41.9	Generalized	No	No	6.8	1.0 ↓	155
154	15 y	Dengue	38.0	Generalized	No	No	4.2	1.1	156
139	27 y	Chikungunya	38.2	No rash	Yes	Yes	3.5 ↓	1.4	153
157	12 y	Chikungunya	38.0	Generalized	Yes	Yes	3.9 ↓	1.4	261
162	30 y	Chikungunya	38.5	Generalized	No	No	6.6	0.6 ↓	163
166	28 d	Chikungunya	38.2	Generalized	Yes	No	10.9	1.4 ↓	277

^aTemperature at the time of admission
^bSevere arthralgia/myalgia defined as intense crying upon movement or touching of limbs in young infants (age under 1 year) and incapacitating joint pain in older children and adults
Abbreviations y years, m months; D days; ↓, low count according to age; ↑, high count according to age

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