Table 1 Summary of carbohydrate-binding proteins of Borrelia spp. recognizing tick or host receptors. The carbohydrate-binding proteins from Borrelia spp. are listed together with the recognized molecule from the vector or the host. Glycoproteins or glycans are listed as the recognized molecules depending on the available information. Majority of proteins from Lyme borreliosis spirochetes are listed; in the case of relapsing fever Borrelia, the bacterial species is defined
From: A bite so sweet: the glycobiology interface of tick-host-pathogen interactions
Borrelia spp. protein | Tick binding partner | Reference |
|---|---|---|
Borrelia vs tick | ||
OspA | TROSPA | [236] |
OspC | SALP15 | [27] |
TSLPI/P8 | Mannose binding lectin (MBL) | [42] |
Vsp33 (B. hermsii) | Unknown receptor in tick SG | [62] |
Borrelia vs host | ||
Bgp (p26) | GAG | [294] |
DbpA (p20) | Decorin/dermatansulfate | |
DbpB (p19) | Decorin/dermatansulfate/chondroitinsulfate | |
Bbk32 | Fibronectin /heparansulfate/dermatansulfate | [63] |
P66 | Integrins | [87] |
OspA | Plasminogen | [296] |
OspC | Plasminogen | |
Enolase | Plasminogen | [299] |
Erps (OspE/F related proteins) | Factor H or FHL protein | [105] |
CRASPs | Factor H | [105] |
PAMPs | Mannose receptor on dendritic cells | [300] |
Unknown | Neolacto-(Gal4GlcNAc3Gal4Glc1)-carrying glycoconjugates in human erythrocytes | [301] |
VspB (B.turicatae) | GAG | [61] |