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Table 2 Geometric (arithmetic) mean household flea counts and percent reduction from baseline

From: Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats

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Mean

Reduction (%)

t-statistic (tdf)

P-value

(Pr > t)

Mean

Reduction (%)

t-statistic (tdf)

P-value

(Pr > t)

Per protocol population

 

Fluralaner + moxidectin (n = 135)

Fipronil (n = 73)

1

6.89 (14.93)

  

6.38 (9.23)

  

2

0.06 (0.51)

99.1 (96.6)

t(186.21) = 24.9

<0.0001

0.50 (1.34)

92.1 (85.5)

t(144) = 13.0

<0.0001

3

0.06 (0.10)

99.1 (99.3)

t(154.39) = 26.4

<0.0001

0.71 (2.44)

88.8 (73.6)

t(131.94) = 10.7

<0.0001

4

0.04 (0.06)

99.5 (99.6)

t(145) = 27.2

<0.0001

0.66 (1.60)

89.7 (82.6)

t(144) = 12.0

<0.0001

5

0.08* (0.18)

98.9 (98.8)

t(168.67) = 25.6

<0.0001

0.87 (2.32)

86.3 (74.9)

t(134.98) = 10.3

<0.0001

Intent to treat population

 

Fluralaner + moxidectin (n = 152)

Fipronil (n = 84)

1

6.82 (14.26)

  

6.44 (10.0)

  

2

0.08 (0.50)

98.9 (96.5)

t(214.76) = 26.6

<0.0001

0.52 (1.46)

91.9 (85.4)

t(166) = 13.4

<0.0001

3

0.06 (0.11)

99.1 (99.3)

t(174.87) = 28.4

<0.0001

0.71 (2.49)

88.9 (75.1)

t(156.73) = 11.2

<0.0001

4

0.03 (0.05)

99.5 (99.6)

t(1628.1) = 29.4

<0.0001

0.61 (1.48)

90.5 (85.2)

t(164) = 13.0

<0.0001

5

0.07 (0.16)

99.0 (98.9)

t(189.22) = 27.7

<0.0001

0.81 (2.15)

87.4 (78.5)

t(163) = 11.2

<0.0001