Visit | Mean | Reduction (%) | t-statistic (tdf) | P-value (Pr > t) | Mean | Reduction (%) | t-statistic (tdf) | P-value (Pr > t) |
---|---|---|---|---|---|---|---|---|
Per protocol population | ||||||||
Fluralaner + moxidectin (n = 135) | Fipronil (n = 73) | |||||||
1 | 6.89 (14.93) | – | 6.38 (9.23) | – | ||||
2 | 0.06 (0.51) | 99.1 (96.6) | t(186.21) = 24.9 | <0.0001 | 0.50 (1.34) | 92.1 (85.5) | t(144) = 13.0 | <0.0001 |
3 | 0.06 (0.10) | 99.1 (99.3) | t(154.39) = 26.4 | <0.0001 | 0.71 (2.44) | 88.8 (73.6) | t(131.94) = 10.7 | <0.0001 |
4 | 0.04 (0.06) | 99.5 (99.6) | t(145) = 27.2 | <0.0001 | 0.66 (1.60) | 89.7 (82.6) | t(144) = 12.0 | <0.0001 |
5 | 0.08* (0.18) | 98.9 (98.8) | t(168.67) = 25.6 | <0.0001 | 0.87 (2.32) | 86.3 (74.9) | t(134.98) = 10.3 | <0.0001 |
Intent to treat population | ||||||||
Fluralaner + moxidectin (n = 152) | Fipronil (n = 84) | |||||||
1 | 6.82 (14.26) | – | 6.44 (10.0) | – | ||||
2 | 0.08 (0.50) | 98.9 (96.5) | t(214.76) = 26.6 | <0.0001 | 0.52 (1.46) | 91.9 (85.4) | t(166) = 13.4 | <0.0001 |
3 | 0.06 (0.11) | 99.1 (99.3) | t(174.87) = 28.4 | <0.0001 | 0.71 (2.49) | 88.9 (75.1) | t(156.73) = 11.2 | <0.0001 |
4 | 0.03 (0.05) | 99.5 (99.6) | t(1628.1) = 29.4 | <0.0001 | 0.61 (1.48) | 90.5 (85.2) | t(164) = 13.0 | <0.0001 |
5 | 0.07 (0.16) | 99.0 (98.9) | t(189.22) = 27.7 | <0.0001 | 0.81 (2.15) | 87.4 (78.5) | t(163) = 11.2 | <0.0001 |