Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats

Table 4 Percent of households with at least one cat initially infested with at least two fleas that were free of fleas at subsequent visits

Treatment group	Households free of fleas (%)
Treatment group	Visit 2	Visit 3	Visit 4	Visit 5
Per protocol population
Fluralaner + moxidectin	95.6	94.1	95.6	93.3
Fipronil	76.7	69.9	68.5	60.3
Lower 97.5% one-sided confidence limit^a	0.0929	0.1388	0.1673	0.2190
P-value for non-inferiority^b	<0.0001	<0.0001	<0.0001	<0.0001
Intent to treat population
Fluralaner + moxidectin	94.7	93.4	96.0	93.9
Fipronil	75.0	70.2	69.5	61.7
Lower 97.5% one-sided confidence limit^a	0.1046	0.1337	0.1682	0.2169
P-value for non-inferiority^b	<0.0001	<0.0001	<0.0001	<0.0001

^aLower 97.5% one-sided confidence limit was well above the non-inferiority limit of -0.15. If the lower confidence limit was above -0.15, non-inferiority was concluded. If the lower confidence limit was above 0, superiority was concluded
^bFarrington-Manning method

ISSN: 1756-3305