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Table 4 Percent of households with at least one cat initially infested with at least two fleas that were free of fleas at subsequent visits

From: Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats

Treatment group Households free of fleas (%)
Visit 2 Visit 3 Visit 4 Visit 5
Per protocol population
 Fluralaner + moxidectin 95.6 94.1 95.6 93.3
 Fipronil 76.7 69.9 68.5 60.3
 Lower 97.5% one-sided confidence limita 0.0929 0.1388 0.1673 0.2190
P-value for non-inferiorityb <0.0001 <0.0001 <0.0001 <0.0001
 Intent to treat population
 Fluralaner + moxidectin 94.7 93.4 96.0 93.9
 Fipronil 75.0 70.2 69.5 61.7
 Lower 97.5% one-sided confidence limita 0.1046 0.1337 0.1682 0.2169
P-value for non-inferiorityb <0.0001 <0.0001 <0.0001 <0.0001
  1. aLower 97.5% one-sided confidence limit was well above the non-inferiority limit of -0.15. If the lower confidence limit was above -0.15, non-inferiority was concluded. If the lower confidence limit was above 0, superiority was concluded
  2. bFarrington-Manning method