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Table 1 Ranking and prioritisation features employed to infer drug targets and associated drugs in S. haematobium

From: Interactive online application for the prediction, ranking and prioritisation of drug targets in Schistosoma haematobium

Feature Default (cut-off) value Ranking type Weighting
Transcribed in adult worms? Yes Require na
Sequence similarity to C. elegans ortholog ≥ 80% Weighted 5
Sequence similarity to D. melanogaster ortholog ≥ 80% Weighted 5
Sequence similarity to M. musculus ortholog ≥ 80% Exclude na
Sequence similarity to S. japonicum ortholog ≥ 80% Weighted 7
Sequence similarity to S. mansoni ortholog ≥ 80% Weighted 8
Sequence similarity to C. sinensis ortholog ≥ 80% Weighted 6
Sequence similarity to O. viverrini ortholog ≥ 80% Weighted 6
Sequence similarity to F. hepatica ortholog ≥ 80% Weighted 8
Sequence similarity to Swiss-Prot ortholog ≥ 80% Weighted 7
Sequence coverage of C. elegans ortholog ≥ 50% Weighted 5
Sequence coverage of D. melanogaster ortholog ≥ 50% Weighted 5
Sequence coverage of M. musculus ortholog ≥ 50% Exclude na
Sequence coverage of S. japonicum ortholog ≥ 50% Weighted 7
Sequence coverage of S. mansoni ortholog ≥ 50% Weighted 8
Sequence coverage of C. sinensis ortholog ≥ 50% Weighted 6
Sequence coverage of O. viverrini ortholog ≥ 50% Weighted 6
Sequence coverage of F. hepatica ortholog ≥ 50% Weighted 8
Sequence coverage of Swiss-Prot ortholog ≥ 50% Weighted 7
Sequence similarity to human ortholog ≤ 75th percentile? Yes Require na
Lethal phenotype for C. elegans ortholog? Yes Weighted 9
Lethal phenotype for D. melanogaster ortholog? Yes Weighted 9
Lethal phenotype for M. musculus ortholog? No Exclude na
KEGG ‘choke-point’? Yes Weighted 8
Unique InterPro identifier? Yes Weighted 7
One associated compound in ChEMBL? Yes Require na
More than five associated compounds in ChEMBL? Yes Weighted 5
One associated compound in DrugBank? Yes Require na
More than five associated compounds in DrugBank? Yes Weighted 5
  1. For each feature, the default value or cut-off value, the ranking type chosen in this work and the assigned weighting are given. For the inference of de novo drug targets (i.e. those without associated drugs), the last four listed features (i.e. those describing the number of associated compounds) were all set to “exclude”
  2. Abbreviation: na, not applicable