Table 1 Ranking and prioritisation features employed to infer drug targets and associated drugs in S. haematobium
Feature | Default (cut-off) value | Ranking type | Weighting |
|---|---|---|---|
Transcribed in adult worms? | Yes | Require | na |
Sequence similarity to C. elegans ortholog | ≥ 80% | Weighted | 5 |
Sequence similarity to D. melanogaster ortholog | ≥ 80% | Weighted | 5 |
Sequence similarity to M. musculus ortholog | ≥ 80% | Exclude | na |
Sequence similarity to S. japonicum ortholog | ≥ 80% | Weighted | 7 |
Sequence similarity to S. mansoni ortholog | ≥ 80% | Weighted | 8 |
Sequence similarity to C. sinensis ortholog | ≥ 80% | Weighted | 6 |
Sequence similarity to O. viverrini ortholog | ≥ 80% | Weighted | 6 |
Sequence similarity to F. hepatica ortholog | ≥ 80% | Weighted | 8 |
Sequence similarity to Swiss-Prot ortholog | ≥ 80% | Weighted | 7 |
Sequence coverage of C. elegans ortholog | ≥ 50% | Weighted | 5 |
Sequence coverage of D. melanogaster ortholog | ≥ 50% | Weighted | 5 |
Sequence coverage of M. musculus ortholog | ≥ 50% | Exclude | na |
Sequence coverage of S. japonicum ortholog | ≥ 50% | Weighted | 7 |
Sequence coverage of S. mansoni ortholog | ≥ 50% | Weighted | 8 |
Sequence coverage of C. sinensis ortholog | ≥ 50% | Weighted | 6 |
Sequence coverage of O. viverrini ortholog | ≥ 50% | Weighted | 6 |
Sequence coverage of F. hepatica ortholog | ≥ 50% | Weighted | 8 |
Sequence coverage of Swiss-Prot ortholog | ≥ 50% | Weighted | 7 |
Sequence similarity to human ortholog ≤ 75th percentile? | Yes | Require | na |
Lethal phenotype for C. elegans ortholog? | Yes | Weighted | 9 |
Lethal phenotype for D. melanogaster ortholog? | Yes | Weighted | 9 |
Lethal phenotype for M. musculus ortholog? | No | Exclude | na |
KEGG ‘choke-point’? | Yes | Weighted | 8 |
Unique InterPro identifier? | Yes | Weighted | 7 |
One associated compound in ChEMBL? | Yes | Require | na |
More than five associated compounds in ChEMBL? | Yes | Weighted | 5 |
One associated compound in DrugBank? | Yes | Require | na |
More than five associated compounds in DrugBank? | Yes | Weighted | 5 |