Fig. 3

MCC950 affected the levels of ALT/AST, liver granuloma and body weight of infected mice. a Gross appearance of the liver and spleen from all mice. b Liver and spleen indexes, and spleen length. c MCC950 affected the serum transaminases (ALT/AST) levels of infected mice. d Liver tissues were fixed and stained with HE. Arrows indicate granulomatous lesions and arrowheads indicate schistosome eggs. The quantitative analyses were conducted under phase contrast microscope. e Dynamic curves of the body weights from different group mice. ^{#, d}P < 0.05, ^**,&&P < 0.01vs 0W; ^fP < 0.05, ^eeP < 0.01, ^bbbP < 0.001 vs 5W; ^cP < 0.05, ^ccP < 0.01, ^cccP < 0.001. Data were mean ± SEM of 6 mice/group. (b-d) ^***,###P < 0.001 vs N; ^aaP < 0.01, ^bbbP < 0.001 vs SJ; ^&&P < 0.01, ^&&&P < 0.001 vs M4. Abbreviations: N, control group; SJ, infected group; NS, no statistical significance. Scale-bars: d, 100 μm